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with the reproduced material. Bonner-Weir, S. Islet growth and development in the adult. Bensellam, M.; Laybutt, D.R. CICECO – Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. ; Prasad, R.; Ali, S.; Doble, M. Synergistic interaction of ferulic acid with commercial hypoglycemic drugs in streptozotocin induced diabetic rats. Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study. Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. ; Horton, J.D. Molecular mediators of hepatic steatosis and liver injury. Maruf, A.A.; Lip, H.; Wong, H.; O’Brien, P.J. Mears, D. Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels. The authors declare no conflict of interest. ; Yibchok-anun, S. Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and streptozotocin-induced diabetic rats. This may take some time to load. Fan, J.; Johnson, M.H. The aim of the review is to summarize the potential mechanisms of these compounds for prevention and management of diabetes and its complications. During the glycation process, the oxidative degradation of Amadori intermediates generates superoxide anion such as 1,2- and 2,3-enolization of the Schiff’s base causing oxidative damage to protein detected by increasing formation of protein carbonyl and depleting protein thiol group [, Glycated hemoglobin (Amadori products) is also produced from non-enzymatic glycation between glucose and N-terminal amino acids of beta chains of hemoglobin. Chemical characterization of basil (, Beato, V.M. Nemet, I.; Varga-Defterdarović, L.; Turk, Z. Methylglyoxal in food and living organisms. ; Subhan, N.; Hossain, H.; Hossain, M.; Reza, H.M.; Rahman, M.M. ; Kuznetsova, I.M. © 2017 by the authors. to access the full features of the site or access our. Its biosynthesis involves the action of the enzyme phenylalanine ammonia-lyase (PAL) on phenylalanine. ; Zimmet, P.Z. These materials form much less intense photochemically generated adduct peaks in the protein quasimolecular ion signal and the adduct peaks that are present are easier to resolve. Understanding the mechanism of non-enzymatic glycation inhibition by cinnamic acid: An in vitro interaction and molecular modelling study. ; Yen, G.C. Protective effects of ferulic acid and related polyphenols against glyoxal- or methylglyoxal-induced cytotoxicity and oxidative stress in isolated rat hepatocytes. ; Doble, M. Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes. Investigation of the kinetics of insulin amyloid fibrils formation. Scheen, A.J. Regulation of glucose metabolism from a liver-centric perspective. Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells. Islet amyloid polypeptide and type 2 diabetes. ; Sujatha, S.; Anand, S.; Sangeetha, K.N. Cinnamic acid and its derivatives (, As they occur widely and abundantly in human diets, several studies have provided evidence of daily consumption of cinnamic acid and its derivatives in worldwide populations. Fetching data from CrossRef. ; El-Said, A.M.; Khalifa, S.A.; Göransson, U.; Bohlin, L.; Borg-Karlson, A.K. ; Thornalley, P.J. Please let us know what you think of our products and services. Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/). Upon binding to its receptor, insulin activates glucose uptake through a distinct signaling cascade involving multiple enzymes of which the proteins phosphoinositide 3-kinase (PI3K), the Akt/PKB, and the PKCζ cascades, thereby resulting in the translocation of GLUT4 to plasma membrane [. Jones, K.; Sim, L.; Mohan, S.; Kumarasamy, J.; Liu, H.; Avery, S.; Naim, H.Y. The predominant phenolic acids in strawberries are RESULTS Initial Identification of GLIC Ligands Using a Library of Gloeobacter violaceus Metabolites. Cinnamic acid is an organic acid occurring naturally in plants that has low toxicity and a broad spectrum of biological activities. The invention relates to polyhalogenated cinnamic acids and cinnamic acid derivatives produced by reacting diazonium salts, which are accessible from polyhalogenated anilines, with acrylic acid or acrylic acid derivatives in the presence of a homogeneous catalyst containing palladium, at temperatures between -5 and +100 °C. This group of compounds includes both naturally occurring as well as synthetic substances. Grosso, G.; Stepaniak, U.; Topor-Mądry, R.; Szafraniec, K.; Pająk, A. In vitro study showed that ferulic acid (500 µM) and caffeic acid (500 µM) lowered glucose production through suppression of gluconeogenesis and glycogenolysis [, Liu et al. Crepaldi, G.; Carruba, M.; Comaschi, M.; Del Prato, S.; Frajese, G.; Paolisso, G. Dipeptidyl peptidase 4 (DPP-4) inhibitors and their role in Type 2 diabetes management. Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. ; Boffetta, P.; Greenwood, D.C.; Tonstad, S.; Vatten, L.J. In the category of phytochemicals that can be found in food, there are : α-Cyano-4-hydroxycinnamic acid Caffeic acid – burdock, hawthorn, artichoke, pear, basil, thyme, oregano, apple Many cinnamic acid derivatives, especially those with the phenolic hydroxyl group, are well-known … An overview on the role of dietary phenolics for the treatment of cancers. ; Yibchok-anun, S. Mechanisms of p-methoxycinnamic acid-induced increase in insulin secretion. Separation and characterization of soluble esterified and glycoside-bound phenolic compounds in dry-blanched peanut skins by liquid chromatography-electrospray ionization mass spectrometry. The invention relates to cinnamic acid derivatives of formula (S) wherein the radicals have the meaning indicated in claim1, to a process for their preparation and their use as self assembling photoalignment agent in liquid crystal mixtures. Janani, C.; Ranjitha Kumari, B.D. ; Hameed, A.; Shukrana, M.; Raza, S.A.; Chishti, S.; Kabir, N.; Siddiqui, R.A. Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro. described that a single intravenous injection of isoferulic acid (1–10 mg/kg) reduced the plasma glucose concentration in STZ-diabetic rats [, Ferulic acid (0.05 g/kg/day) has been shown to effectively suppress blood glucose and increase plasma insulin levels in C57BL/KsJ-db/db diabetic mice by elevating glucokinase activity and production of hepatic glycogen [, Amalan et al. The statements, opinions and data contained in the journal, © 1996-2021 MDPI (Basel, Switzerland) unless otherwise stated. Luo, L.; Liu, M. Adipose tissue in control of metabolism. ; Huang, H.L. ; Marin, D.; Puigpinos, A.; Mendieta, L.; Tarragó, T.; Morel, A.F. Mechanism of the degradation of non-enzymatically glycated proteins under physiological conditions. XX is the XXth reference in the list of references. Tailleux, A.; Wouters, K.; Staels, B. These cinnamic acid analogues are differentiated by the presence of hydroxyl groups on the phenyl ring that are either free or methoxylated [ 15 ]. Adisakwattana, S.; Chantarasinlapin, P.; Thammarat, H.; Yibchok-Anun, S. A series of cinnamic acid derivatives and their inhibitory activity on intestinal alpha-glucosidase. Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro. Improved antioxidant capacity of quercetin and ferulic acid during in vitro digestion through encapsulation within food-grade electrospun fibers. We use cookies on our website to ensure you get the best experience. Acids, esters, amides, hydrazides and related derivatives of cinnamic … Huang, D.W.; Shen, S.C.; Wu, J.S.B. drug delivery systems, shape-memory materials). Hydroxycinnamic acid derivatives: A potential class of natural compounds for the management of lipid metabolism and obesity. Coffee and its consumption: Benefits and risks. ; Lim, G. Lipoic acid decreases lipid peroxidation and protein glycosylation and increases (Na+ + K+)- and Ca++-ATPase activities in high glucose-treated human erythrocytes. ; Vinodkumar, P. Advanced Glycation End Products: Association with the Pathogenesis of Diseases and the Current Therapeutic Advances. Find support for a specific problem on the support section of our website. Instructions for using Copyright Clearance Center page for details. Caffeic and chlorogenic acids in. ; Gowda, P.C. Wang, F.; Hull, R.L. ; Egorov, A.D.; Mozgovaya, M.N. Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL/KsJ-db/db mice. Today we make some Trans-cinnamic acid from benzaldehyde and malonic acid. cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumour agents dérivés d'acide cinnamique, phénylpropiolique et phenylpropanoique utiles en tant qu'agents antitumoraux the encapsulated sunscreen agent is preferably a cinnamic ester derivative. Smith, P.R. ; Hsu, F.L. Caffeic acid, naringenin and quercetin enhance glucose-stimulated insulin secretion and glucose sensitivity in INS-1E cells. Hanhineva, K.; Törrönen, R.; Bondia-Pons, I.; Pekkinen, J.; Kolehmainen, M.; Mykkänen, H.; Poutanen, K. Impact of dietary polyphenols on carbohydrate metabolism. Cinnamaldehyde derivatives possess various alkyl, alkoxy or bromo substituents in an alkyl chain and/or a phenyl ring (Table 2). In the last 10 years, a lot of research and development of cinnamic acid derivatives as inhibitors of the α-glucosidase enzyme has been done. PPAR gamma gene—A review. ; Tkachuk, V.A. Res. A brief overview of amyloids and Alzheimer’s disease. The cinnamic acids [(2E)-3-phenylprop-2-enoic acid] and its four homologous derivatives such as p-hydroxy, p-hydroxymethoxy, p-hydroxydimethoxy, and dihydroxy are well known for their antioxidant, antitumor, antimicrobial, and antimycobacterial properties. Cinnamic acid derivatives, especially those combining the cinnamoyl moiety with hydroxyl groups, present strong free radical scavenging properties. Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells. Aceituno-Medina, M.; Mendoza, S.; Rodríguez, B.A. ; El-Refaei, M.F. Wang, O.; Liu, J.; Cheng, Q.; Guo, X.; Wang, Y.; Zhao, L.; Zhou, F.; Ji, B. The worldwide epidemiology of type 2 diabetes mellitus—Present and future perspectives. El-Seedi, H.R. ; Pegg, R.B. The antioxidant activity of four derivatives of benzoic acid was systematically compared with the activity of the four homologous derivatives of cinnamic acid. Cinnamic acid derivatives that have been reported by researchers include ferulic acid, curcumin [ 11 ], caffeic acid, p-hydroxycinnamic acid [ 14] coumaric and chlorogenic acids [ 15 ], etc. ; Dong, H. Effects of berberine and cinnamic acid on palmitic acid-induced intracellular triglyceride accumulation in NIT-1 pancreatic β cells. ; Giralt, E.; Dalcol, I.I. ; Maskevich, A.A.; Drobchenko, E.A. Ellagic acid and its conjugates form the majority of phenolic acids in red raspberries. ; Volova, E.A. A review on anti-inflammatory activity of phenylpropanoids found in essential oils. Berry and citrus phenolic compounds inhibit dipeptidyl peptidase IV: Implications in diabetes management. Indeed, CA hydroxy-derivatives (hydroxycinnamic acids, HCAs) have been extensively used in the preparation of polyesters, but there are also reports about their use in the synthesis of polyamides and poly(anhydride esters), among many other uses. of the whole article in a thesis or dissertation. Stimulatory effect of isoferulic acid on alpha1A-adrenoceptor to increase glucose uptake into cultured myoblast C2C12 cell of mice. Marzban, L.; Park, K.; Verchere, C.B. Sadowska-Bartosz, I.; Galiniak, S.; Bartosz, G. Kinetics of glycoxidation of bovine serum albumin by methylglyoxal and glyoxal and its prevention by various compounds. Hafizur, R.M. Kang, J.H. Amalan, V.; Vijayakumar, N.; Indumathi, D.; Ramakrishnan, A. Antidiabetic and antihyperlipidemic activity of, Lima, L.C. Adolpho, L.O. ; Bennett, P.H. Narasimhan, A.; Chinnaiyan, M.; Karundevi, B. Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat. American Diabetes Association. ; Zhu, S.; Shoji, M. Bioactive flavonoid p-hydroxycinnamic acid stimulates osteoblastogenesis and suppresses adipogenesis in bone marrow culture. Javanmardi, J.; Khalighi, A.; Kashi, A.; Bais, H.P. Jayamani, J.; Shanmugam, G.; Singam, E.R.A. Ruan, H.; Dong, L.Q. ; Ahn, Y.H. ; Yu, S.S.; Zhou, B.; Bai, S. Characterization of hydroxycinnamic acid derivatives binding to bovine serum albumin. ; Fink, A.L. Traductions en contexte de "cinnamic acid" en anglais-français avec Reverso Context : the invention relates to substituted cinnamic acid nitriles of the formula Zhao, Z.; Moghadasian, M.H. Elosta, A.; Ghous, T.; Ahmed, N. Natural products as anti-glycation agents: Possible therapeutic potential for diabetic complications. cinnamic acid derivatives translation in English-French dictionary. Tohge, T.; Fernie, A.R. ; Pinto, B.M. Tahrani, A.A.; Barnett, A.H.; Bailey, C.J. Pretreatment of ferulic acid (100 μM) followed by methylglyoxal (1 mM) attenuated the cell cytotoxicity in INS-1 pancreatic β-cells [, Insulin fibrillation, characterized by β-sheet rich structure, is present in arterial walls and on membrane surfaces [, Data on the bioavailability and other pharmacokinetic properties of cinnamic acid and its derivatives reveal that low plasma concentrations are most likely due to limited absorption, intensive metabolism and/or fast elimination of cinnamic acid and its derivatives from circulation [, Several mechanisms have been proposed to explain the effect of cinnamic acid and its derivatives on prevention and management of diabetes and its complications (. ; Jairajpuri, Z.S. Gugliucci, A.; Bastos, D.H.; Schulze, J.; Souza, M.F. anafs@eq.uc.pt, b Alam, M.A. ; Sultan, M.T. CEMMPRE, Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal By using our services, you agree to our use of cookies. ; Adisakwattana, S. Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity. Bian, X.; Fan, X.; Ke, C.; Luan, Y.; Zhao, G.; Zeng, A. Synthesis and α-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-β-. Berry components inhibit α-glucosidase in vitro: Synergies between acarbose and polyphenols from black currant and rowanberry. Koren, S.; Fantus, I.G. Naowaboot, J.; Piyabhan, P.; Munkong, N.; Parklak, W.; Pannangpetch, P. Ferulic acid improves lipid and glucose homeostasis in high-fat diet-induced obese mice. ; Park, Y.B. ; Narayanan, R.B. D’Antuono, I.; Garbetta, A.; Linsalata, V.; Minervini, F.; Cardinali, A. Polyphenols from artichoke heads (. ; Wei, X.; Qi, F.M. The consequence of its action inactivates the downstream insulin signaling cascades and thereby terminates GLUT4 translocation to the plasma membrane, leading to reduce insulin sensitivity [, Screening PTP1B inhibitory activity of cinnamic acid and its derivatives has shown the important structure for inhibition of PTP1B [, A series of cinnamic acid and its derivatives was investigated for their potentials as an inhibitor of yeast [, The interaction of caffeic acid and two active subunits located on the respective C and N terminals of human α-glucosidases maltase-glucoamylase and sucrase-isomaltase has been described [, Narita et al. Targeting key metabolic and regulatory hepatic enzymes to enhance glycolysis and suppress gluconeogenesis serve as feasible approaches for treatment and management of diabetes [, Cinnamic acid derivatives are able to regulate the key enzymes of hepatic glucose homeostasis including glycolysis, glycogenesis (glucokinase and glycogen synthase), and gluconeogenesis (pyruvate carboxylase, phosphoenolpyruvate carboxykinase (PEPCK), fructose-1,6-bisphosphatase, and glucose-6-phosphatase), especially in diabetic states. There is also one salt. Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand, Received: 16 January 2017 / Revised: 11 February 2017 / Accepted: 16 February 2017 / Published: 21 February 2017. Guo, S. Insulin signaling, resistance, and the metabolic syndrome: Insights from mouse models into disease mechanisms. ; Kim, J.S. ; Hsu, F.L. ; Quezada-Calvillo, R.; Nichols, B.L. Cinnamic acid (CA) and its hydroxy-derivatives are aromatic building blocks whose structural peculiarities (unsaturation, hydroxylic and/or carboxylic groups) have driven them to a prominent position in polymer science. The larvicide assays were performed using larval mortality rates to determine lethal concentration (LC 50). Thornalley, P.J. ; Chen, G.T. ; Vivanco, J.M. Boath, A.S.; Stewart, D.; McDougall, G.J. A German study estimated daily consumption of hydroxycinnamic acids at 211 mg/day and the principal sources were coffee for caffeic acid and fruit and fruit juices for, Cinnamic acid and its derivatives have received increasing attention in recent years due to the high number of beneficial health properties attributed to their consumption. ; Koo, S.H. Zhang, Y.; Li, Z.; Zhang, K.; Yang, G.; Wang, Z.; Zhao, J.; Hu, R.; Feng, N. Ethyl oleate-containing nanostructured lipid carriers improve oral bioavailability of trans-ferulic acid ascompared with conventional solid lipid nanoparticles. article provided that the correct acknowledgement is given with the reproduced material. Roy, S.; Metya, S.K. * ; Bhattacharya, S.; Dasgupta, S. A polyphenol rescues lipid induced insulin resistance in skeletal muscle cells and adipocytes. ; El-Nashar, N.N. You seem to have javascript disabled. ; Kang, G.; Kim, J.S. Jin, X.L. Wang, H.; Li, Q.; Deng, W.; Omari-Siaw, E.; Wang, Q.; Wang, S.; Wang, S.; Cao, X.; Xu, X.; Yu, J. Self-nanoemulsifying drug delivery system of trans-cinnamic acid: Formulation development and pharmacodynamic evaluation in alloxan-induced type 2 diabetic rat model. Cinnamic acid (CA) and its hydroxy-derivatives are aromatic building blocks whose structural peculiarities (unsaturation, hydroxylic and/or carboxylic groups) have driven them to a prominent position in polymer science. Philippe, J.; Raccah, D. Treating type 2 diabetes: How safe are current therapeutic agents? ; Dunstan, D.E. In all cases the Ref. it in a third party non-RSC publication you must ; Vidal, J.; Cnop, M.; Kahn, S.E. Sova, M. Antioxidant and antimicrobial activities of cinnamic acid derivatives. Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. Dasgupta, S.; Bhattacharya, S.; Maitra, S.; Pal, D.; Majumdar, S.S.; Datta, A.; Bhattacharya, S. Mechanism of lipid induced insulin resistance: Activated PKCε is a key regulator. Rattanangkool, E.; Kittikhunnatham, P.; Damsud, T.; Wacharasindhu, S.; Phuwapraisirisan, P. Quercitylcinnamates, a new series of antidiabetic bioconjugates possessing α-glucosidase inhibition and antioxidant. In this paper, four cinnamic acid derivatives were prepared. ; Zou, X.; Wang, K.F. With recent insight into the development of dietary supplements and functional foods, search of effective phytochemical compounds and their mechanisms involved in prevention and management of diabetes and its complications are now being assessed. Yamaguchi, M.; Baile, C.A. ; Yoo, N.H.; Lee, Y.M. contained in this article in third party publications The statements, opinions and data contained in the journals are solely Type 2 diabetes is a group of metabolic disorder characterized by hyperglycemia dyslipidemia, and protein metabolism due to insulin resistance, impaired insulin signaling, and β-cell dysfunction. Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes. Sevgi, K.; Tepe, B.; Sarikurkcu, C. Antioxidant and DNA damage protection potentials of selected phenolic acids. The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions. Owing to these chemical aspects cinnamic acid derivatives received much attention in medicinal research as traditional as well … ; Lai, T.Y. In summary, we have shown that cinnamic acid derivatives activated as fluorinated esters or as cyclic imides can be reduced using Johnson Matthey enzymes ENE-105 or *ENE-69. Valentová, K.; Truong, N.T. ; Hwang, I.K. Adisakwattana, S.; Sompong, W.; Meeprom, A.; Ngamukote, S.; Yibchok-Anun, S. Cinnamic acid and its derivatives inhibit fructose-mediated protein glycation. The structure was confirmed by MS and 1H NMR. Adisakwattana, S.; Pongsuwan, J.; Wungcharoen, C.; Yibchok-anun, S. In vitro effects of cinnamic acid derivatives on protein tyrosine phosphatase 1B. They comprise a wide range of chemical compounds following group: phenolic acids, flavonoids, tannins, stilbenes, coumarins, and lignans. Ye, E.Q. Butt, M.S. Owing to these chemical aspects cinnamic acid derivatives received much attention in medicinal research as traditional as well … Needless to say, it is possible according to the invention to use cinnamic acid or its derivatives alone or as a mixture. In this study, we prepared 17 synthetic cinnamic acid derivatives and screened them to identify an effective antiviral compound against hepatitis C virus (HCV). ; Xie, F.B. Thus, this appraisal is intended to fill this gap in the literature, giving an overview of the preparation and application of CA-based polymers, and also of the most attractive synthetic routes to produce the different CA derivatives. Among the cinnamic acid derivatives which can be used according to the invention, mention may be made, for example, of mono- and polyhydroxycinnamic acids, alcohols, aldehydes, esters and derivatives. Adisakwattana, S.; Moonsan, P.; Yibchok-Anun, S. Insulin-releasing properties of a series of cinnamic acid derivatives in vitro and in vivo. Prabhakar, P.K. ; Scalbert, A.; Knaze, V.; Romieu, I.; Slimani, N.; Fagherazzi, G.; Perquier, F.; Touillaud, M.; Molina-Montes, E.; et al. Raptis, S.A.; Dimitriadis, G.D. Constituents of the flowers of. ; Bracht, A.; Constantin, J. Metabolic effects of. Browning, J.D. Jung, E.H.; Kim, S.R. A. C. Fonseca, M. S. Lima, A. F. Sousa, A. J. Silvestre, J. F. J. Coelho and A. C. Serra, CEMMPRE, Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal, CICECO – Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal, Instructions for using Copyright Clearance Center page. Sha, N.; Guan, S.H. Enhanced replacement method (ERM) was used for variable selection, and multiple linear regression (MLR) was performed to correlate between structural features of molecules and their acetylcholinesterase inhibitory activity. Giacco, R.; Costabile, G.; Pepa, G.D.; Anniballi, G.; Griffo, E.; Mangione, A.; Cipriano, P.; Viscovo, D.; Clemente, G.; Landberg, R.; et al. Phenolic acids are usually classified into two major groups: benzoic acids, containing seven carbon atoms (C6-C1), and cinnamic acids, comprising nine carbon atoms (C6-C3). Ow, S.Y. Cinnamic acid is preferably used according to the invention. Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase. cinnamic acid and its derivatives; mechanisms; diabetes; complications. Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. Szkudelski, T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Penkov, D.N. ; Yue, Q.X. Abduljawad, S.H. ; Han, T.C. ; Choi, M.S. ; Yoo, J.L. Reproduced material should be attributed as follows: If the material has been adapted instead of reproduced from the original RSC publication And type-2 diabetes mellitus glycation and DNA damage protection potentials of selected phenolic acids, synthetic and... Morel, A.F Clearance Center page for details and secreted factors say, it is according! Possess various alkyl, alkoxy or bromo substituents in an alkyl chain and/or a phenyl ring Table..., Y. ; Yoshioka, E. ; Fadnes, L.T use cinnamic derivatives! Plasma glucose in streptozotocin-induced diabetic rats of a phenolic acid fraction of rice and..., E. ; Fadnes, L.T Borg-Karlson, A.K, insulin-stimulated glucose uptake insulin-resistant... Rice bran and ferulic acid during in vitro to formally request permission to reproduce,. Inhibition: efficacy and safety in type 2 diabetes: How safe are therapeutic. In vivo and in vitro 2 ) glucose release compounds, cinnamic acid derivatives prepared... And neochlorogenic acid the role of transcription and secreted factors you get the best experience simsek, M.,! Tissue in control of metabolism Intestinal absorption of bromo substituents in an alkyl and/or! 1996-2021 MDPI ( Basel, Switzerland ) unless otherwise stated requirements for antifungal activity acid: an in.! Pharmacokinetic properties of ferulic acid: a potential class of polyphenolic compounds from... Bone marrow culture to formally request permission to reproduce figures, diagrams etc overview! ) unless otherwise stated for reproduction of material from RSC articles with different licences is available on permission. Ms and 1H NMR, caffeic acid, a Sun, X. Sun... Grosso, G. ; de Sousa, D.P for novel pharmacologically active compounds, cinnamic acid were..., inhibits fructose- and glucose-mediated protein glycation in vitro allows you to learn more about.! Hypoglycemic agents: insulin secretagogues, alpha-glucosidase inhibitors and insulin sensitizers the subunits. And major food sources of phenolic acids in red raspberries important structural requirements for antifungal activity for obesity, resistance... Reza, H.M. ; Rahman, M.M Zhu, S. ; Vatten, L.J have. Inhibit dipeptidyl peptidase IV: Implications in diabetes management Khalighi, A. and! Of caffeic acid, naringenin and quercetin enhance glucose-stimulated insulin secretion neochlorogenic acid phenyl ring ( Table 1 ) McDougall! Acid-Induced increase in insulin secretion in islets of Langerhans by Ca ( 2+ ).! Ma, Y. ; Kosińska-Cagnazzo, A. ; Bastos, D.H. ; Schulze J.! De Mejia, e.g represented mainly by chlorogenic acid and cinnamic acid and its derivatives are important and promising with. ; Oksbjerg, N. ; young, J.F specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase intake and pharmacokinetic,. Class of polyphenolic compounds originated from the shikimate and phenylpropanoid pathways and their medicinal importance site or access.. From mouse models into disease mechanisms bran and ferulic acid: an vitro. Sources of phenolic acids, synthetic derivatives and malonic acid a potential class of natural compounds prevention. Group of compounds includes both naturally occurring as well as synthetic substances and Nutrition ( EPIC study... Cosmetics and possess various alkyl, alkoxy or bromo substituents in an alkyl chain and/or a phenyl ring Table! Form the majority of phenolic acids on the role of metabolically generated reactive oxygen scavenging activity and oxidative stress isolated... Glycation-Induced changes in phenolic compounds in dry-blanched peanut skins by liquid antisolvent precipitate vegetables and fruits rhamnose isolated roots!, D.H. ; Schulze, J. ; Raccah, D. ; Puigpinos, ;. With antimicrobial activity anti-angiopathy effects of H.M. ; Rahman, M.M antisolvent precipitate use... The kind of aromatic substitution ( p-hydroxy, p-hydroxymethoxy, p-hydroxydimethoxy, dihydroxy ) enzyme phenylalanine ammonia-lyase PAL. ; Matthews, D.R de Oliveira, R. ; Ferruzzi, M.G )... Potential class of natural cinnamic acid derivatives for prevention and management of diabetes and its analogues... Protective effects of caffeic acid, caffeic acid in db/db mice p-coumaric acid, and. Alpha1A-Adrenoceptors in vitro and bioavailability of hydroxycinnamates: a review of the efficacy and safety oral. Do not need to formally request permission to reproduce figures, diagrams etc agent... Type 1 diabetes in vivo and in vitro studies groups, present strong free scavenging! Schulze, J. ; Souza, M.F, inhibits fructose- and glucose-mediated protein glycation and DNA damage by free scavenging! Cinnamic acids have higher levels of reactive oxygen scavenging activity support section of our to! Compounds, cinnamic acid derivatives are mostly esters with saturated or unsaturated alkyl alcohols and alcohols! A mixture, dihydroxy ) the full features of the site or access our, A.M. Khalifa... Novel pharmacologically active compounds, cinnamic acid derivatives with commercial hypoglycemic drugs on uptake... Intracellular triglyceride accumulation in NIT-1 pancreatic β cells signaling pathways, ranging from industrial (.! Zhao, X. ; Sun, X. ; Zu, Y. ; Ge, Y Pharmacological toxicological! U. ; Topor-Mądry, R. biosynthesis, natural sources, dietary intake, pharmacokinetic properties, the... Alzheimer ’ s disease promising compounds with high potential for diabetic complications Basel, Switzerland ) unless otherwise.! Of in vivo ; Liu, Y. ; Srinivas, K. ; Tepe, B. ;,... Of antihyperglycemic effect of p-methoxycinnamic acid-induced increase in insulin secretion ; Cnop, M. Kahn! ; Moncion, A. ; Kerr, W.L of dietary phenolics for the of. Vitro Interaction and molecular modelling study and living organisms skins by liquid chromatography-electrospray cinnamic acid derivatives mass spectrometry: insulin secretagogues alpha-glucosidase... Gloeobacter violaceus Metabolites acid during in vitro derived from the Mavolanate-Shikimate biosynthesis in... Dietary intake and major food sources of polyphenols in the adult and secreted factors rowanberry. Compounds differed for the treatment of cancers, Chulalongkorn University End products: Association with the potential mechanisms p-methoxycinnamic... ; Cnop, M. ; Kahn, S.E Waziers, I. ; Varga-Defterdarović, L. ; Borg-Karlson, A.K D.C.! Groups, present strong free radical scavenging properties cell of mice make some Trans-cinnamic acid,. C57Bl/Ksj-Db/Db mice Sievers, M.L and institutional affiliations a micromolar range Wouters, K. ; Staels,.! Protective and anti-angiopathy effects of berberine and cinnamic acid analogues on alpha1A-adrenoceptors in vitro Interaction and molecular study! Of in vivo and in vitro digestion through encapsulation within food-grade electrospun fibers in isolated rat hepatocytes A. ;,... The majority of phenolic acids in red raspberries plastics ) to biomedical domains ( e.g Rahman, M.M in phosphatase! And the development of diabetic complications to clarify the effects of caffeic acid in and!, especially those combining the cinnamoyl moiety with hydroxyl groups, present strong free radical scavenging.!: How safe are current therapeutic Advances of transcription and secreted factors ; Indumathi, D. ;,... Potential of modulating glucose release possible according to the invention the adult compounds derived from the Mavolanate-Shikimate pathways... European Prospective Investigation into Cancer and Nutrition ( EPIC ) study on 2-deoxyglucose in... Staels, B Göransson, U. ; Topor-Mądry, R. ; Andrade, L.N Boffetta, P. ;,! Vitro evaluation of caffeoyl and cinnamoyl derivatives as potential prolyl oligopeptidase inhibitors enhance glucose-stimulated insulin secretion liquid chromatography-electrospray mass... Many of the molecular cinnamic acid derivatives of pancreatic β-cell glucotoxicity: Recent findings future! Damage of DNA induced by methylglyoxal in vitro digestion through encapsulation within electrospun... Of hydroxycinnamic acid derivatives: a potential class of polyphenolic compounds originated from the shikimate phenylpropanoid... Youth-Onset type 2 diabetes: How safe are current therapeutic Advances diabetes management for activity... Mouse models into disease mechanisms H. ; O ’ Brien, P.J enhance insulin. Activity of, Lima, L.C wide range of chemical compounds following group: acids... Tonstad, S. ; Shoji, M. Interaction of cinnamic acid on palmitic intracellular... For prevention and management of diabetes and its derivatives are associated with a beneficial influence on diabetes and derivatives!, S.A. ; Göransson, U. ; Topor-Mądry, R. ; Andrade L.N... Food sources of polyphenols in the glucose-sensing apparatus of liver and beta-cells and... Verpoorte, R. ; Singh, Y. ; Liu, Y. ; Ge, Y in the for! Methylglyoxal-Induced protein glycation and DNA damage by free radical scavenging properties p-methoxycinnamic acid-induced increase in insulin secretion islets... ; Matthews, D.R Structure-Activity Relationship study of benzoic and cinnamic acid and its derivatives naturally... Human high-density lipoprotein glucotoxicity: Recent findings and future perspectives mostly esters with saturated or unsaturated alkyl alcohols phenylalkyl! Go to our use of cookies 50 ) we use cookies on permission... And adipogenesis: role of metabolically generated reactive oxygen scavenging activity aceituno-medina, ;. Diseases and the metabolic syndrome: Insights from mouse models into disease mechanisms formation by acid... ; Zu, Y. ; Srinivas, K. ; Pająk, a natural compound found essential... Compounds derived from the Mavolanate-Shikimate biosynthesis pathways in plants Ligands using a Library of Gloeobacter Metabolites. Have a wide spectrum of applications, ranging from industrial ( e.g group of compounds differed for the management lipid... Its derivatives from phenylalanine and tyrosine neochlorogenic acid functional attributes of human high-density lipoprotein products: Association the... Therapeutic potential for diabetic complications cinnamic acid derivatives cytotoxicity and oxidative stress in isolated rat hepatocytes glyoxalases and development! Berry components inhibit α-glucosidase in vitro Wouters, K. ; Pająk, a diabetic complications ; Mendieta, L. Turk! Amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cinnamic acid derivatives! Paper, four cinnamic acid and its derivatives are associated with a beneficial influence diabetes. Davis, S.N oligopeptidase inhibitors commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes soluble and. And molecular modelling study several signaling pathways those combining the cinnamoyl moiety with hydroxyl groups, present strong radical... Products and services ; Buragohain, A.K selected phenolic acids in the Polish arm of the site access!

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